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1

Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase

William Holland, Thomas Morrison, Ying Chang, Nicholas Wiernsperger, Bradley J Stith

Journal:

Biochemical Pharmacology

Year:

2004

Language:

english

File:

PDF, 192 KB

english, 2004

2

The Antihyperglycaemic Effect of Metformin

Wiernsperger, Nicolas F., Bailey, Clifford J.

Journal:

Year:

1999

Language:

english

File:

PDF, 265 KB

english, 1999

3

Review: 50 years later: is metformin a vascular drug with antidiabetic properties?

Wiernsperger, N. F

Journal:

The British Journal of Diabetes & Vascular Disease

Year:

2007

Language:

english

File:

PDF, 421 KB

english, 2007

4

The Effects of Metformin on the Capillary Permeability to Albumin in Women Patients with Cyclic Edema

Valensi, P., Behar, A., Andre, P., Wiernsperger, N., Attali, J.-R.

Journal:

Year:

1995

Language:

english

File:

PDF, 483 KB

english, 1995

5

An insulin sensitizer improves the free radical defense system potential and insulin sensitivity in high fructose-fed rats

Faure, P., Rossini, E., Wiernsperger, N., Richard, M. J., Favier, A., Halimi, S.

Journal:

Year:

1999

Language:

english

File:

PDF, 63 KB

english, 1999

6

Metformin delays the manifestation of diabetes and vascular dysfunction in Goto–Kakizaki rats by reduction of mitochondrial oxidative stress

Peter Rösen, Nicolas F. Wiernsperger

Journal:

Diabetes/Metabolism Research and Reviews

Year:

2006

Language:

english

File:

PDF, 176 KB

english, 2006

7

Characterization of metformin transport system in NIH 3T3 cells

Naim A. Khan, Nicolas Wiernsperger, Veronique Quemener, René Havouis, Jacques P. Moulinoux

Journal:

Journal of Cellular Physiology

Year:

1992

Language:

english

File:

PDF, 686 KB

english, 1992

8

Effects of metformin on bile salt transport by monolayers of human intestinal Caco-2 cells

D. Carter, H. C. S. Howlett, N. F. Wiernsperger, C. Bailey

Journal:

Diabetes, Obesity and Metabolism

Year:

2002

Language:

english

File:

PDF, 142 KB

english, 2002

9

Differential effects of metformin on bile salt absorption from the jejunum and ileum

D. Carter, H. C. S. Howlett, N. F. Wiernsperger, C. J. Bailey

Journal:

Diabetes, Obesity and Metabolism

Year:

2003

Language:

english

File:

PDF, 184 KB

english, 2003

10

Docosahexaenoic Acid Is a Major n-3 Polyunsaturated Fatty Acid in Bovine Retinal Microvessels

Marc Lecomte, Clarisse Paget, Daniel Ruggiero, Nicolas Wiernsperger, Michel Lagarde

Journal:

Journal of Neurochemistry

Year:

1996

Language:

english

File:

PDF, 1.18 MB

english, 1996

11

Description of anin vitroangiogenesis model designed to test antiangiogenic molecules

B. Vailhé, X. Ronot, M. Lecomte, N. Wiernsperger, L. Tranqui

Journal:

Cell Biology and Toxicology

Year:

1996

Language:

english

File:

PDF, 379 KB

english, 1996

12

Effect of glycated LDL on microvascular tone in mice: a comparative study with LDL modified in vitro or isolated from diabetic patients

P. Nivoit, N. Wiernsperger, P. Moulin, M. Lagarde, C. Renaudin

Journal:

Year:

2003

Language:

english

File:

PDF, 246 KB

english, 2003

13

Hyperglycaemia modifies the reaction of microvessels to insulin in rat skeletal muscle

C. Renaudin, E. Michoud, J. R. Rapin, M. Lagarde, N. Wiernsperger

Journal:

Year:

1998

Language:

english

File:

PDF, 275 KB

english, 1998

14

Potentiating effect of metformin on insulin-induced glucose uptake and glycogen metabolism within Xenopus oocytes

D. Detaille, N. Wiernsperger, P. Devos

Journal:

Year:

1998

Language:

english

File:

PDF, 237 KB

english, 1998

15

Defects in microvascular haemodynamics during prediabetes: contributor or epiphenomenon?

N. Wiernsperger

Journal:

Year:

2000

Language:

english

File:

PDF, 126 KB

english, 2000

16

EFFECTS OF NAFTIDROFURYL ON ISOLATED PERFUSED KIDNEYS OF SPONTANEOUSLY HYPERTENSIVE RATS

B. L. Zhang, K. L. Liu, J. Sacquet, N. Wiernsperger, D. Benzoni, J. Sassard

Journal:

Clinical and Experimental Pharmacology and Physiology

Year:

1993

Language:

english

File:

PDF, 572 KB

english, 1993

17

DEMONSTRATION OF DEFECTIVE GLUCOSE UPTAKE AND STORAGE IN ERYTHROCYTES FROM NON-INSULIN DEPENDENT DIABETIC PATIENTS AND EFFECTS OF METFORMIN

René G. Yoa, Jean R. Rapin, Nicolas F. Wiernsperger, Albert Martinand, Ivan Belleville

Journal:

Clinical and Experimental Pharmacology and Physiology

Year:

1993

Language:

english

File:

PDF, 452 KB

english, 1993

18

Metformin improves skin capillary reactivity in normoglycaemic subjects with the metabolic syndrome

L. G. Kraemer de Aguiar, C. M. Laflor, L. Bahia, N. R. Villela, N. Wiernsperger, D. A. Bottino, E. Bouskela

Journal:

Diabetic Medicine

Year:

2007

Language:

english

File:

PDF, 208 KB

english, 2007

19

Biguanide Effects on Insulin Signaling

EMMANUELLE MEUILLET, NICOLAS WIERNSPERGER, PIERRE HUBERT, GÉRARD CRÉMEL

Journal:

Annals of the New York Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 155 KB

english, 1997

20

Sleep Apnea Is Induced by a High-fat Diet and Reversed and Prevented by Metformin in Non-obese Rats

Wiâm Ramadan, Gérard Dewasmes, Michel Petitjean, Nicolas Wiernsperger, Stéphane Delanaud, Alain Geloen, Jean-Pierre Libert

Journal:

Year:

2007

Language:

english

File:

PDF, 415 KB

english, 2007

21

Microvascular haemodynamic reactions to insulin

N. Wiernsperger, E. Bouskela

Journal:

The Journal of Physiology

Year:

2009

Language:

english

File:

PDF, 48 KB

english, 2009

22

The formation of tubular structures by endothelial cells is under the control of fibrinolysis and mechanical factors

Bruno Vailhé, Marc Lecomte, Nicolas Wiernsperger, Léone Tranqui

Journal:

Year:

1998

Language:

english

File:

PDF, 265 KB

english, 1998

23

Microcirculation and the Metabolic Syndrome

N. Wiernsperger, P. Nivoit, L. G. Kraemer De Aguiar, E. Bouskela

Journal:

Microcirculation

Year:

2007

Language:

english

File:

PDF, 233 KB

english, 2007

24

Hyperglycemia and glucosamine-induced mesangial cell cycle arrest and hypertrophy: Common or independent mechanisms?

Elodie Masson, Michel Lagarde, Nicolas Wiernsperger, Samer El Bawab

Journal:

Year:

2006

Language:

english

File:

PDF, 230 KB

english, 2006

25

Oxidative stress: The special case of diabetes

N. F. Wiernsperger

Journal:

Year:

2003

Language:

english

File:

PDF, 44 KB

english, 2003

26

Vascular defects in the aetiology of peripheral insulin resistance in diabetes. A critical review of hypotheses and facts

Nicolas Wiernsperger

Journal:

Diabetes/Metabolism Research and Reviews

Year:

1994

Language:

english

File:

PDF, 1.82 MB

english, 1994

27

Metformin–insulin interactions: From organ to cell

N. Wiernsperger, J. R. Rapin

Journal:

Diabetes/Metabolism Research and Reviews

Year:

1995

Language:

english

File:

PDF, 729 KB

english, 1995

28

Postischemic breakdown in hippocampal protein synthesis and mnesic deficits in rats: Pharmacological improvement by curative naftidrofuryl treatment

Y. Lamproglou, M. Le Poncin, W. Jacques, N. Wiernsperger, J. R. Rapin

Journal:

Metabolic Brain Disease

Year:

1992

Language:

english

File:

PDF, 1.14 MB

english, 1992

29

Technical note about simultaneous recording of oxygen partial pressure and neuronal activity in cat cortex

N. Wiernsperger, S. Kunke, P. Gygax

Journal:

Cellular and Molecular Life Sciences

Year:

1976

Language:

english

File:

PDF, 309 KB

english, 1976

30

Novel findings in the cephalic phase of digestion: A role for microcirculation?

Caroline Buss, Luiz Guilherme Kraemer-Aguiar, Priscila A. Maranhão, Carolina Marinho, Maria das Graças C. de Souza, Nicolas Wiernsperger, Eliete Bouskela

Journal:

Physiology & Behavior

Year:

2012

Language:

english

File:

PDF, 267 KB

english, 2012

31

Obligatory role of membrane events in the regulatory effect of metformin on the respiratory chain function

Dominique Detaille, Bruno Guigas, Xavier Leverve, Nicolas Wiernsperger, Pierre Devos

Journal:

Biochemical Pharmacology

Year:

2002

Language:

english

File:

PDF, 285 KB

english, 2002

32

Cellular and molecular mechanisms involved in insulin’s potentiation of glycogen synthase activity by metformin

Dominique Detaille, Nicolas Wiernsperger, Pierre Devos

Journal:

Biochemical Pharmacology

Year:

1999

Language:

english

File:

PDF, 368 KB

english, 1999

33

Reaction of metformin with dicarbonyl compounds. possible implication in the inhibition of advanced glycation end product formation

Daniel Ruggiero-Lopez, Marc Lecomte, Gérard Moinet, Gérard Patereau, Michel Lagarde, Nicolas Wiernsperger

Journal:

Biochemical Pharmacology

Year:

1999

Language:

english

File:

PDF, 399 KB

english, 1999

34

Metformin modulates insulin receptor signaling in normal and cholesterol-treated human hepatoma cells (HepG2)

Emmanuelle J Meuillet, Nicolas Wiernsperger, Barbara Mania-Farnell, Pierre Hubert, Gerard Cremel

Journal:

European Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 282 KB

english, 1999

35

Metformin interaction with insulin-regulated glucose uptake, using the Xenopus laevis oocyte model expressing the mammalian transporter GLUT4

Dominique Detaille, Nicolas Wiernsperger, Pierre Devos

Journal:

European Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 560 KB

english, 1999

36

Advanced glycation end-products induce apoptosis of bovine retinal pericytes in culture: involvement of diacylglycerol/ceramide production and oxidative stress induction

Ulriche Denis, Marc Lecomte, Clarisse Paget, Daniel Ruggiero, Nicolas Wiernsperger, Michel Lagarde

Journal:

Free Radical Biology and Medicine

Year:

2002

Language:

english

File:

PDF, 182 KB

english, 2002

37

Modification of Enzymatic Antioxidants in Retinal Microvascular Cells by Glucose or Advanced Glycation End Products

Clarisse Paget, Marc Lecomte, Daniel Ruggiero, Nicolas Wiernsperger, Michel Lagarde

Journal:

Free Radical Biology and Medicine

Year:

1998

Language:

english

File:

PDF, 114 KB

english, 1998

38

Impaired Microvascular Responses to Acute Hyperglycemia in Type I Diabetic Rats

Corinne Renaudin, Edouard Michoud, Michel Lagarde, Nicolas Wiernsperger

Journal:

Journal of Diabetes and its Complications

Year:

1999

Language:

english

File:

PDF, 259 KB

english, 1999

39

Vascular Permeability Increase as Induced by Histamine or Bradykinin is Enhanced by Advanced Glycation Endproducts (AGEs)

Erik Svensjö, Fatima Cyrino, Edouard Michoud, Daniel Ruggiero, Eliete Bouskela, Nicolas Wiernsperger

Journal:

Journal of Diabetes and its Complications

Year:

1999

Language:

english

File:

PDF, 239 KB

english, 1999

40

HYPOTENSION INDUCED CHANGES IN CEREBRAL MICROFLOW AND EEG AND THEIR PHARMACOLOGICAL ALTERATIONS.

P. Gygax, N. Wiernsperger

Journal:

Journal of Internal Medicine

Year:

1984

Language:

english

File:

PDF, 452 KB

english, 1984

41

Effect of experimental non-insulin requiring diabetes on myocardial microcirculation during ischaemia in dogs

L. SEBBAG, R. FORRAT, E. CANET, N. WIERNSPERGER, J. DELAYE, S. RENAUD, M. DE LORGERIL

Journal:

European Journal of Clinical Investigation

Year:

1994

Language:

english

File:

PDF, 484 KB

english, 1994

42

Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated rat hepatocytes

Doriane ARGAUD, Hubert ROTH, Nicolas WIERNSPERGER, Xavier M. LEVERVE

Journal:

Year:

1993

Language:

english

File:

PDF, 796 KB

english, 1993

43

Advanced Glycation End Products Induce Specific Glycoprotein Alterations in Retinal Microvascular Cells

Nadege Rellier, Daniel Ruggiero, Marc Lecomte, Michel Lagarde, Nicolas Wiernsperger

Journal:

Biochemical and Biophysical Research Communications

Year:

1997

Language:

english

File:

PDF, 2.74 MB

english, 1997

44

Glycosphingolipid Changes Induced by Advanced Glycation End-Products

Audrey Natalizio, Daniel Ruggiero, Marc Lecomte, Michel Lagarde, Nicolas Wiernsperger

Journal:

Biochemical and Biophysical Research Communications

Year:

2001

Language:

english

File:

PDF, 136 KB

english, 2001

45

The effects of glucose, insulin and metformin on the order parameters of isolated red cell membranes: An electron paramagnetic resonance spectroscopic study

Hans-Joachim Freisleben, Susanne Ruckert, Nicolas Wiernsperger, Guido Zimmer

Journal:

Biochemical Pharmacology

Year:

1992

Language:

english

File:

PDF, 1.22 MB

english, 1992

46

Metformin induces an agonist-specific increase in albumin production by primary cultured rat hepatocytes

Mohamed S. Zaïbi, Prudent Padieu, Martine Chessebeuf-Padieu, Mohammed El Baraka, Nicolas Wiernsperger, Jean-Robert Rapin

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 721 KB

english, 1995

47

Dopaminergic agonists and their influence on the oxygenation and functional activity of underperfused brain tissue

Nicolas Wiernsperger, Peter Gygax, Alfred Schweizer, Max Danzeisen

Journal:

European Journal of Pharmacology

Year:

1979

Language:

english

File:

PDF, 377 KB

english, 1979

48

Involvement of caspase-10 in advanced glycation end-product-induced apoptosis of bovine retinal pericytes in culture

Marc Lecomte, Ulriche Denis, Daniel Ruggiero, Michel Lagarde, Nicolas Wiernsperger

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2004

Language:

english

File:

PDF, 564 KB

english, 2004

49

INHIBITORY EFFECT OF METFORMIN ON VASCULAR SMOOTH MUSCLE CELL DYSFUNCTION INDUCED BY LEPTIN

Jean-Claude Mamputu, Nicolas Wiernsperger, Geneviève Renier

Journal:

Cardiovascular Pathology

Year:

2004

Language:

english

File:

PDF, 55 KB

english, 2004

50

Glomerular proliferation during early stages of diabetic nephropathy is associated with local increase of sphingosine-1-phosphate levels

Karen Geoffroy, Lysiane Troncy, Nicolas Wiernsperger, Michel Lagarde, Samer El Bawab

Journal:

Year:

2005

Language:

english

File:

PDF, 223 KB

english, 2005

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